ISSN 1662-4009 (online)

ey0019.8-2 | New Mechanisms | ESPEYB19

8.2. Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated NR3C1 gene

SG Caradonna , NR Einhorn , V Saudagar , H Khalil , GH Petty , A Lihagen , C LeFloch , FS Lee , H Akil , A Guidotti , BS McEwen , E Gatta , J Marrocco

Transl Psychiatry. 2022; 12(1): 109. PMID: 35296634 https://pubmed.ncbi.nlm.nih.gov/35296634/Brief Summary: This mouse study identified sex and genotype-dependent effects of oral corticosterone on behavioral and physiological outcomes as well as on gene expression and epigenetics in hippocampal subregions.Glucocorticoids exert their effects by binding to glucocorticoid...